The OECD Environmental, Health and Safety (EHS) Programme has been helping member countries to make better use of increased knowledge of how chemicals induce adverse effects in humans and wildlife, through the so-called Adverse Outcome Pathways.
The OECD is actively working on establishing cooperation with scientific journals regarding the review and publication processes of AOPs (Adverse Outcome Pathways). In this series of four videos, the AOP review process is explained as well as the main differences between a journal article peer review and an AOP review as defined by the OECD. Journal editors interested in further cooperation on the AOP Development Programme and on AOP review in particular can contact the Secretariat (ehs.contact@oecd.org).
Seven AOPs were recently published in iLibrary, following scientific review and OECD endorsement:
Published on 12 December 2023:
Published on 23 October 2023:
Published on 11 July 2023:
The OECD launched a new programme on the development of Adverse Outcome Pathways (AOP) in 2012. An AOP is an analytical construct that describes a sequential chain of causally linked events at different levels of biological organisation that lead to an adverse health or ecotoxicological effect (see figure below). AOPs are the central element of a toxicological knowledge framework being built to support chemical risk assessment based on mechanistic reasoning.
Schematic representation of the AOP illustrated with reference to a number of pathways
Watch our video: OECD work on Adverse Outcome Pathway
Access all publications on Adverse Outcome Pathways. Find the OECD Series on Adverse Outcome Pathways on iLibrary .
The Advisory Group on Emerging Science in Chemicals Assessment (ESCA) oversees the essential elements of the AOP Programme. This group works towards the development of AOPs with the support of and in close collaboration with the AOP-KB Coordination Group and of the Society for the Advancement of AOPs (SAAOP). The latter serves as the primary interface between the OECD ESCA and the broader AOP community of practice.
Representation of the AOP Development Process at the OECD
The OECD is developing co-operation with Scientific Journals for the review and publication of AOPs.
This cooperation is formalised in the signature of a Memorandum of understanding (MOU). Scientific Journal Signatories take part in the scientific review of AOPs relevant to their field of expertise, with the view to achieve the following common objectives:
The conditions of the MOU are summarised here.
The following Journals have already signed an MOU with the OECD:
The OECD's AOP Knowledge Base tools, constantly developed and refined, are a web-based platform which aims to bring together all knowledge on how chemicals can induce adverse effects, therefore providing a focal point for AOP development and dissemination.
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Test Guidelines Programme The for the identification of new biomaker endpoints and in vitro test methods that are candidates to become part of OECD Test Guidelines. |
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