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  • 4-July-2023

    English

    Test No. 240: Medaka Extended One Generation Reproduction Test (MEOGRT)

    This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs).  Exposure in the MEOGRT starts with spawning fish (P or F0 generation) and continues until hatching (until two weeks post fertilization, wpf) in the second (F2) generation. This Test Guideline measures several biological endpoints.  Primary emphasis is given to potential adverse effects on population relevant parameters including survival, gross development, growth and reproduction (fecundity).  Secondarily, in order to provide mechanistic information and provide linkage between results from other kinds of field and laboratory studies, where there is a posteriori evidence for a chemical having potential endocrine disrupter activity (e.g. androgenic or oestrogenic activity in other tests and assays) then other useful information is obtained by measuring vitellogenin (vtg) mRNA (or vitellogenin protein, VTG), phenotypic secondary sex characteristics (SSC) as related to genetic sex, and evaluating histopathology.
  • 30-June-2023

    English

    OECD Biotechnology Update

    Read our newsletter to stay up-to-date with all the latest OECD work on biotechnology.

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  • 28-June-2023

    English

    Webinar Series on Emerging Science to Improve Chemical Safety

    Report on the WNT Workshop how to prepare the Test Guidelines Programme for emerging technologies | In December 2022, the OECD held a workshop to explore where and how to adapt the Test Guidelines to emerging technologies, and remain relevant and impactful. A number of projects and activities are emanating from this workshop discussions, including the revision of Guidance Document 34 on validation, and more to come.

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  • 27-June-2023

    English

    OECD work on in vitro assays for developmental neurotoxicity

    Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery | This document includes the lessons learned from the application of this technology in the field of pharmaceuticals and considers a range of issues directly relevant to human exposure arising from the application of externally-applied dsRNA-based pesticides, and discusses possible effects of dsRNA exposure in mammals.

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  • 27-June-2023

    English

    OECD Conference on RNAi based Pesticides

    Considerations for the Human Health Risk Assessment of Externally Applied ds-RNA-Based Pesticides | This report includes lessons learned from the application of this technology in the field of pharmaceuticals and considers a range of issues directly relevant to human exposure arising from the application of externally-applied dsRNA-based pesticides. It also discusses possible effects of dsRNA exposure in mammals.

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  • 5-June-2023

    English

    The costs and benefits of regulating chemicals

    The OECD has set up the Surveys on Willingness-to-Pay to Avoid Negative Chemicals-Related Health Impacts (SWACHE) project to establish comparable values for the willingness-to-pay to avoid negative health effects due to exposure to chemicals. The health effects valued include asthma, infertility, IQ loss, chronic kidney disease, and very low birth weight.

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  • 5-May-2023

    English

    Publications in the series on Pollutant Release and Transfer Registers

    Countries are taking action against toxic chemicals emitted into air, water and land by industry. How can countries track progress made towards this target? The new OECD report looks at Pollutant Release and Transfer Registers data as a means to track toxic releases to monitor chemical pollution in order to meet the United Nations Sustainable Development Goal Target 12.4.

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  • 27-April-2023

    English

    Children’s Health

    Children can be more vulnerable to environmental hazards posed by chemicals, due to their physiological differences and unique behaviour. This document presents the results of a survey conducted in 2021, aiming to identify currently available methodologies for assessing the risk of chemicals to children’s health and also identify possible needs for additional or missing parameters and for further guidance documents.

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  • 15-March-2023

    English

    Safety of novel foods and feeds and on the harmonisation of regulatory oversight in biotechnology

    These two documents compile information on activities related to the assessment of the safety of products derived from modern biotechnology, environmental safety (biosafety) and the safety of novel foods and feeds, at the international level between April 2021 and May 2022. The information was provided by OECD Members, partner countries and observer organisations participating in the work.

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  • 5-December-2022

    English

    Occupational Biomonitoring

    This report presents current approaches used to derive biomonitoring values and provides globally harmonised recommendations on how-to derive and apply occupational biomonitoring assessment values. It is relevant for occupational health professionals and occupational safety and health specialists, regulatory authorities, industry, researchers, and stakeholders interested in addressing occupational and general population biomonitoring.

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