Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated
Approaches to Testing and Assessment
With a view to assisting the evaluation of integrated approaches to testing and assessment
(IATA) in regulatory decision-making within OECD Member Countries, this guidance document
provides a set of principles for reporting defined approaches to testing and assessment
that can be used as one of the components within IATA. Templates are also provided
to enable a structured approach to their documentation in order to facilitate their
evaluation. A defined approach to testing and assessment consists of a fixed data
interpretation procedure (DIP) applied to data generated with a defined set of information
sources to derive a result that can either be used on its own, or together with other
information sources within an IATA, to satisfy a specific regulatory need. Thus, a
defined approach to testing and assessment can be used to support the hazard identification,
hazard characterisation and/or safety assessment of chemicals. This guidance is intended
to be used alongside similar guidance aimed at harmonising the reporting of other
IATA components such as QSARs, grouping and read-across strategies, and non-guideline
in vitro methods.