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Reports


  • 7-March-2024

    English

    Section 4: Health Effects

    Interested parties are invited to send their comments on the Draft Updated TG 437, Draft Updated TG 467 and Draft updated supporting Document for TG 467 by 7 and 6 March February 2024.

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  • 15-February-2024

    English

    Draft Guidance and Review Documents/Monographs

    Interested parties are invited to send their comments on the Draft Performance Standards for assessment of proposed similar or modified in vitro skin sensitisation Epidermal Sensitisation Assay (EpiSensA) test methods by 15 February 2024.

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  • 21-December-2023

    English

    Biocides publications (Chronological order)

    The Covid-19 pandemic has challenged regulators, health professionals, industry and the public in responding quickly, decisively and efficiently to the impact and consequences of this virus. This report looks at the lessons learned during the Covid-19 crisis to investigate approaches for possible future emergency situations.

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  • 20-December-2023

    English

    Series on Risk Management - Publications by number

    The series on Risk Management covers methodologies for both governments and industry to manage risks posed by chemicals and, when appropriate, to harmonise risk management activities. The OECD provides information on the following areas: perfluorinated chemicals, substitution of hazardous chemicals, sustainable chemistry and others.

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  • 12-December-2023

    English

    Adverse Outcome Pathways

    The OECD released three new Adverse Outcome Pathways following scientific review and OECD endorsement.

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  • 12-December-2023

    English

    Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis

    Lung fibrosis is a dysregulated or exaggerated tissue repair process resulting in the thickening or scarring of lung tissue. It involves the presence of sustained or repeated exposure to a stressor and intricate dynamics between several inflammatory and immune response cells, and the microenvironment of the alveolar-capillary region consisting of both immune and non-immune cells, and the lung interstitium. This AOP is applicable to a broad group of stressors of diverse properties e.g. metal dusts, pharmacological products, fibres, microorganisms, chemicals, including novel technology-enabled stressors such as nanomaterials. This AOP is referred to as AOP 173 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).

  • 12-December-2023

    English

    Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation

    This adverse outcome pathway links inhibition of aromatase activity in teleost fish during gonadogenesis to increased differentiation to testis resulting in a male-biased sex ratio in the population, and ultimately, reduced population sustainability. Most gonochoristic fish species develop either as males or females and do not change sex throughout their life span. However, in species where sexual differentiation is controlled at least to some degree by environmental factors, there can be a window of development during gonadal differentiation that is sensitive to a variety of exogenous conditions. During this window, endocrine active chemicals, aromatase inhibitors in particular, have the potential to alter gonad development and sex differentiation. This AOP is referred to as AOP 346 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).

  • 12-December-2023

    English

    Adverse Outcome Pathway on Androgen receptor agonism leading to male-biased sex ratio

    This adverse outcome pathway links androgen receptor agonism in teleost fish during gonadogenesis to male-biased sexual differentiation and consequently, reduced population growth rate. Sex determination in teleost fishes is highly plastic; it can be genetically or environmentally influenced. Species with environmentally-based sex determination in particular can be very sensitive to exogenous chemicals during the period of differentiation. Exogenous hormones are of ecological concern because they have the potential to alter gonad development and sex differentiation. This AOP is referred to as AOP 376 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).

  • 22-November-2023

    English

    Pesticides publications (Chronological order)

    This guidance document collates a variety of existing information regarding the registration of pesticides for minor uses in a centralised document.

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  • 23-October-2023

    English

    Adverse Outcome Pathway on impaired interleukin-1 receptor type I (IL-1R1) signaling leading to impaired T-cell dependent antibody response

    Stressors that exhibit immunosuppression might act by different mechanisms, i.e. alter the number of cells involved in the immune response, the ability of the cells to produce cytokines, chemokines, antibodies or growth factors, the composition of the subpopulations of cells present at the site of the response, or the function of the cells. This Adverse Outcome Pathway (AOP) describes how impairment of the signaling receptor IL-1R1 in T cells can lead to impaired T cell activation and antibody production, leading to increased susceptibility to infection. The AOP focuses on the blocking of binding of IL-1 to IL-1R1, leading to the Inhibition of Nuclear factor kappa B (NF-kB). This AOP is referred to as AOP 277 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).
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